|
Breast Carcinoma
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Low nuclear ATM protein level was significantly associated with aggressive breast cancer including larger tumors, higher tumor grade, higher mitotic index, pleomorphism, tumor type, lymphovascular invasion, estrogen receptor (ER)-, PR -, AR -, triple-negative, and basal-like phenotypes (Ps < .05).
|
25425972 |
2014 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
ATM protein expression was analyzed by immunohistochemistry in 17 breast carcinomas with two monoclonal antibodies whose immunohistochemical use was first validated by comparing the immunoreactivity observed in spleen samples from ataxia telangiectasia and trauma patients.
|
10999741 |
2000 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Tumours with low ATM or high ATR levels in conjunction with MYC overexpression also have worse overall breast cancer-specific survival (BCSS) (p value < 0.05).
|
30746633 |
2019 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to investigate ATM expression in breast carcinomas and its relationship to neoangiogenesis.
|
16329039 |
2006 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Reduced expression of ATM and MSH2 compromises DNA repair capacity and, thereby, increases breast cancer prevalence.
|
27466510 |
2016 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
As BRCA1 and BRCA2 are also components of the genome maintenance network and their mutations predispose to breast cancer, we have examined the ATM expression in human breast carcinomas of BRCA1/2 mutation carriers, sporadic cases and familial non-BRCA1/2 patients.
|
17982490 |
2008 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
ATM was activated in 45% of normal tissue samples, 70% of preneoplastic lesions, and 14% of breast carcinomas.
|
19884805 |
2010 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
No evidence was found that the reduction in ATM protein levels seen in breast carcinoma is the result of epigenetic silencing.
|
17593081 |
2007 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that Triptolide specifically chemosensitizes breast cancer cells to Doxorubicin prior to apoptosis initiation through downregulating ATM expression and inhibiting DNA damage response.
|
29500880 |
2018 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
This increase was not related to the constitutive ATM mRNA level, which was similar in these BC and the normal cell lines.
|
15101044 |
2004 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
On the basis of the clinical data, we conducted siRNA knockdown to study the role of ERα on ATM expression in breast cancer cell lines.
|
23857602 |
2013 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Although sporadic mutation of ATM occurs rarely in breast cancer, the status of its protein expression and its clinical significance in breast cancer remain not well established.
|
25935535 |
2015 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The ATM gene expression was down-regulated in breast cancer tissues and a high ATM gene expression level in breast cancer tissue was associated with a favorable prognosis.
|
17366603 |
2007 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The data suggest that ATM protein expression is an independent prognostic marker in sporadic BC.
|
24285016 |
2014 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Loss of ATM expression or inhibiting oxidized ATM kinase activity reduced breast cancer cell migration and invasion.
|
30562756 |
2018 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Lymphoid tumours and breast cancer in ataxia telangiectasia; substantial protective effect of residual ATM kinase activity against childhood tumours.
|
21792198 |
2011 |
|
Breast Carcinoma
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
This high rate of somatic inactivation of ATM may indicate either that these rare variants play a role in breast cancer development or alternatively that a neighboring tumor suppressor gene is important for tumorigenesis.
|
10534763 |
1999 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
In summary, our data show that ATM and p53 coordinately regulate FOXM1 via E2F to modulate epirubicin response and resistance in breast cancer.
|
21518729 |
2011 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Development of a biologically active monoclonal antibody (6313/G2) against the AT1 receptor prompted the testing of a recombinant short-chain variable fragment form (R6313/G2) against breast cancer cells in vitro and in vivo.
|
18310294 |
2008 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical analysis included nuclear exclusion of FOXO3 as a marker of follicle activation, γH2AX as a marker of DNA damage, meiotic recombination 11 (MRE11), ataxia telangiectasia mutated (ATM), Rad51, breast cancer susceptibility 1 (BRCA1) and breast cancer susceptibility 2 (BRCA2) as DNA repair factors.
|
30521029 |
2019 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
To test this hypothesis, we investigated 1406 ER(+) early-stage breast cancers with 20 years' long-term clinical follow-up data for DNA polymerase β (pol β), flap endonuclease 1 (FEN1), AP endonuclease 1 (APE1), X-ray cross-complementation group 1 protein (XRCC1), single-strand monofunctional uracil glycosylase-1 (SMUG1), poly (ADP-ribose) polymerase 1 (PARP1), ataxia telangiectasia mutated and Rad3 related (ATR), ataxia telangiectasia mutated (ATM), DNA-dependent protein kinase catalytic subunit (DNA-PKcs), Chk1, Chk2, p53, breast cancer susceptibility gene 1 (BRCA1), and topoisomerase 2 (TOPO2) expression.
|
25111287 |
2014 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
ATM, a serine-threonine kinase, controls the cellular response to DNA double-strand breaks, and has been implicated in breast cancer risk.
|
18701470 |
2008 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
This study suggested that some antioxidant vitamins intake may modify the effect of ATM diplotype on the breast cancer risk among Korean women.
|
21058196 |
2010 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Testing for the ATM gene is unlikely to be useful for predicting clinical response to radiotherapy in breast cancer patients.
|
9683358 |
1998 |